Onyx is now licensed to manufacture commercial API from our UK facility

Your molecule, our people – it’s good chemistry

Your molecule, our people – it’s good chemistry

Your molecule, our people – it’s good chemistry

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About us: Small molecule CDMO

Onyx Scientific is a small molecule CDMO specialising in process R&D, non-GMP scale up and GMP manufacture for clinical trials and commercial. Good chemistry is at the core of everything we do. From our facilities in the UK and US, our teams of chemists will guide your small molecule API through development and manufacturing from the moment a lead molecule is identified, taking it into Phase I studies and right through to commercial manufacture.

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Solid state chemistry

Solid state chemistry is required to understand and control the physical properties of a drug substance and achieve API synthesis. An in-depth understanding of the API is developed through screening work (including salt screening if applicable) where our high throughput methodology ensures a wide range of counterions and solvents are studied.  Solubility is a key parameter throughout this work and detailed solubility testing will help in selecting the correct version of API for onward study. Understanding the range of forms an API can take and their properties is also crucial to deciding on a chosen candidate. Polymorph screening provides this information by producing a detailed form diagram which summarises the findings. Crystallisation development then ensures that the chosen version and form can be generated reproducibly.

 

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Knowledge hub

Here at Onyx our experts are committed to bringing you their latest insights from the API development and manufacturing world. In our knowledge hub you can find an array of content curated to help you overcome challenges and achieve success.

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News

Onyx bolsters capabilities with commercial API manufacturing license

Onyx Scientific, a small molecule API contract development and manufacturing […]

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Insights

Contract API manufacturing: a shifting landscape

The pharmaceutical industry is evolving and the outsourcing landscape is changing with it. For larger pharmaceutical companies there is a trend towards scaling back their internal capabilities and ...

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