Onyx Scientific is a small molecule CDMO specialising in process R&D, non-GMP scale up and GMP manufacture for clinical trials and commercial. Good chemistry is at the core of everything we do. From our facilities in the UK and US, our teams of chemists will guide your small molecule API through development and manufacturing from the moment a lead molecule is identified, taking it into Phase I studies and right through to commercial manufacture.
Solid state chemistry is required to understand and control the physical properties of a drug substance and achieve API synthesis. An in-depth understanding of the API is developed through screening work (including salt screening if applicable) where our high throughput methodology ensures a wide range of counterions and solvents are studied. Solubility is a key parameter throughout this work and detailed solubility testing will help in selecting the correct version of API for onward study. Understanding the range of forms an API can take and their properties is also crucial to deciding on a chosen candidate. Polymorph screening provides this information by producing a detailed form diagram which summarises the findings. Crystallisation development then ensures that the chosen version and form can be generated reproducibly.
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